肠-大脑轴和术后认知功能障碍:对微生物群,炎症和认知健康的多因素视角
Rhythm Joshi1, Nishkarsh Gupta2, Anju Gupta3
1Department of Anesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi 110029, Delhi, India.
概括
手术后认知功能障碍 (POCD) 可能受到肠道健康的影响. 使用益生菌 (如Akkermansia muciniphila) 恢复肠道微生物群平衡,有望改善手术后的大脑恢复.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 手术后认知功能障碍 (POCD) 是一个普遍的问题,特别是在老年手术患者中.
- 肠-大脑轴,一种双向通信通道,越来越多地被认为是它在认知功能中的作用.
- 肠道微生物群的代谢物,如短链脂肪酸和神经递质,显著影响大脑健康和认知.
研究的目的:
- 审查肠道微生物群和POCD之间的关系.
- 探索肠道健康恢复的潜力,以减轻POCD.
- 突出特定益生菌,如Akkermansia muciniphila在术后大脑恢复中的作用.
主要方法:
- 对11项选定的研究进行了系统审查.
- 对肠-大脑轴机制的分析.
- 评估肠道失调对POCD的影响.
- 对肠道健康和认知功能的益生菌干预措施的评估.
主要成果:
- 手术,麻醉和抗生素使用后的肠道微生物群障碍 (失生症) 可以导致神经炎症和POCD.
- 阿克尔曼西亚 (Akkermansia muciniphila) 通过加强肠道屏障和减少炎症,显示出有益的作用.
- 益生菌干预措施,包括Akkermansia muciniphila和VSL#3,显示出预防或减少POCD的潜力.
结论:
- 肠道健康与手术后的大脑恢复密切相关.
- 通过益生菌向肠道微生物群是管理POCD的有希望的治疗策略.
- 需要进一步的临床研究,为手术患者建立个性化的益生菌治疗方法.
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