瘤坏死因子-阿尔法 (TNF-α) 抑制剂在上腺炎中的治疗:对并发症风险的基于人口的回顾性队列研究
Sreeya Reddy1, Caleb Beckham2, Sahil Kapur3
1Dermatology, Texas Tech University Health Sciences Center El Paso, El Paso, USA.
瘤亡因子-α (TNF-α) 抑制剂可以改善辅助性腺炎 (HS),但与结核病,炎症性肠病和牛皮的风险增加有关. 需要进一步的研究来了解长期的安全性.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对瘤亡因子-α (TNF-α) 的单克隆抗体已经彻底改变了水炎补充性 (HS) 治疗.
- 在HS患者中使用TNF-α抑制剂的综合安全性需要进一步研究.
研究的目的:
- 评估TNF-α抑制剂使用与中度至重度HS患者新发并发症的发生率之间的关联.
- 评估TNF-α抑制剂治疗后出现特定疾病的风险,包括感染和自身免疫性疾病.
主要方法:
- 一项使用TrinetX数据库的回顾性队列研究.
- 鉴定了15416名接受TNF-α抑制剂 (infliximab,adalimumab,certolizumab pegol,golimumab) 治疗的HS患者和201,737名未接受治疗的对照.
- 倾向性得分匹配被用来平衡群体之间的基线特征.
主要成果:
- 使用TNF-α抑制剂与结核病 (RR 3.15),炎症性肠病 (RR 9.35) 和牛皮 (RR 5.36) 的风险显著增加有关.
- 没有观察到机会性感染的显著增加.
- 还评估了新发自免疫性肝炎和沙尔科毒症,具体风险比率在摘要中没有详细说明.
结论:
- 在HS患者中,TNF-α抑制剂治疗与患结核病和炎症性肠病等特定并发症的风险增加有关.
- 这些发现强调了警的临床监测和对潜在不良事件的患者咨询的重要性.
- 建议进行纵向研究,以进一步阐明与HS生物疗法相关的长期安全性和并发症发展.
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