血清炎症生物标志物可以预测患有败血症相关的胃肠道功能障碍的患者的临床结果
You-Hui Liu1, Qing-Yang Chen1, Fei-Yue Dai1
1Department of Intensive Care Unit, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
World journal of gastrointestinal surgery
|March 11, 2026
概括
血清炎症生物标志物 (SIB) 强烈预测肠道功能障碍 (GID) 的败血症患者的结果. 升高的SIB与更差的预后相关,有助于临床决策.
科学领域:
- 临界护理医学 临界护理医学
- 胃肠病学 胃肠病学
- 生物标志物研究 生物标志物研究
背景情况:
- 败血症引起的胃肠道功能障碍 (GID) 缺乏有效的预测指标.
- 识别可靠的标志物对于管理GID的败血症患者至关重要.
研究的目的:
- 评估血清炎症生物标志物 (SIBs) 与毒引起的GID患者的临床结果之间的关系.
- 评估SIBs在这个人群中预后的预测性能.
主要方法:
- 分析了117名败血症诱导的GID患者,根据预后 (差与好) 分类,使用APACHE II评分.
- 血清炎症生物标志物 (PCT,CRP,IL-6,IL-10,TNF-α) 被测量并与APACHE II和SOFA分数相关联.
- 多变量分析和ROC曲线确定了SIBs对临床结果的预测值.
主要成果:
- 预后不佳的患者显示APACHE II,SOFA,PCT,CRP,IL-6,IL-10和TNF-α的水平明显更高.
- SIBs与APACHE II和SOFA分数都显示出正相关性.
- 综合SIB分析实现了0.906的结果预测曲线下的面积,优于单个标志物.
结论:
- 血清炎症生物标志物与败血症诱导的GID的临床结果密切相关.
- 包括PCT,CRP,IL-6和TNF-α在内的SIBs作为预后的独立预测因素.
- 这些发现凸显了SIBs在改善患者管理和预测结果方面的潜力.
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