基于脂质体水凝的口服疫苗,用于有针对性的诱导肠粘膜免疫力
Zhiwei Li1, Baochao Fan2,3, Chengcheng Ouyang1
1School of Pharmacy, Nanjing Tech University, Nanjing, 211816, China.
Materials today. Bio
|March 11, 2026
概括
一种新的口服疫苗输送平台使用装饰着曼诺斯的脂质体和酸盐的凝微球,增强了对猪流行性腹病毒 (PEDV) 的粘膜和全身免疫力. 这种方法为口服针对肠道疾病的疫苗提供了一个有希望的策略.
科学领域:
- 生物技术是生物技术.
- 疫苗学 疫苗学 疫苗学
- 材料科学 材料科学 材料科学
背景情况:
- 口服疫苗提供方便的管理和粘膜免疫,但面临来自胃肠道环境的挑战.
- 开发有效的口服疫苗输送系统对于对抗肠道传染病至关重要.
研究的目的:
- 开发和评估一种用于增强粘膜和全身免疫力的新型口服疫苗输送平台.
- 克服胃肠道屏障和酸性条件对口服疫苗有效性的限制.
主要方法:
- 使用用抗原和视网酸复合的,装饰着曼诺斯的脂质体,包裹在硫化酸盐凝微球 (MLip@Gel) 中,创建了一个输送系统.
- 该系统通过曼诺斯装饰向肠道巨细胞,并通过酸盐凝外保护抗原免受胃部降解.
- 疗效在小鼠和小猪身上进行了测试,评估了包括IgA,IgG和T/B细胞激活在内的免疫反应,随后进行了挑战实验.
主要成果:
- MLip@Gel系统在酸性条件下表现出稳定性,在pH≥6.8.8的情况下释放抗原.
- 在小鼠中,PR-MLip@Gel显著增加了α4β7+CCR9+细胞激活,IgA,IgG和CD4+/CD8+T/B细胞水平.
- 用PR-MLip@Gel免疫的小猪对猪流行性腹病毒 (PEDV) 感染的保护得到了增强,表明粘膜和幽默免疫力强大.
结论:
- 这种新型口服疫苗输送平台有效诱导强烈的粘膜和全身免疫反应.
- 这一系统为开发口服疫苗来预防像PEDV这样的肠道传染病提供了一个有希望的策略.
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