增长分化因子11重编程M2型巨细胞:针对癌症治疗的免疫代谢
Saeed Mohammadi1, Mahmoud Darweesh1, Ahmed Al-Harrasi2
1Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman.
World journal of gastroenterology
|March 11, 2026
概括
增长分化因子11 (GDF11) 重编程与瘤相关的M2巨细胞,逆转它们的前瘤功能. 这种免疫代谢调节为癌症和相关的炎症性疾病提供了一种新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢途径 代谢途径
- 癌症生物学 癌症生物学
背景情况:
- 瘤微环境通常含有类似M2的巨细胞,促进癌症的进展.
- 功能障碍的M2巨细胞有助于慢性炎症和代谢障碍.
研究的目的:
- 调查生长分化因子11 (GDF11) 在瘤微环境中的M2类巨细胞调节中的作用.
- 探索GDF11作为治疗癌症和相关代谢功能障碍的治疗剂的潜力.
主要方法:
- 用GDF治疗M2类巨细胞11.
- 对Smad2/3通路激活的分析.
- 评估M2标志物 (CD206) 的表达.
- 评估细胞代谢参数,包括线粒体功能,胆固醇含量和反应性氧物种 (ROS) 生产.
- 对秘密体对肝细胞癌 (HCC) 细胞的影响的分析.
主要成果:
- 在M2型巨细胞中,GDF11治疗激活了Smad2/3通路.
- GDF11诱导了巨细胞身份的转变,降低了CD206的表达.
- 代谢重编程包括增强线粒体呼吸,降低细胞胆固醇,增加ROS产量.
- 经GDF11重编程的巨细胞分泌了抑制HCC细胞增殖和迁移的因素.
结论:
- GDF11作为一种非细胞毒性免疫代谢调节剂,重编程瘤前的M2类巨细胞.
- GDF11显示出作为直接瘤抑制和解决M2巨相关疾病的双轴治疗剂的潜力.
- 这种基于机制的方法可能为管理恶性瘤和慢性炎症提供一种新的策略.
更多相关视频
08:37Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
Published on: April 18, 2025
1.2K
09:57Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
Published on: January 29, 2019
23.5K
相关概念视频
Differentiation of Common Myeloid Progenitor Cells
4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K
mTOR Signaling and Cancer Progression
5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
5.0K
Mitogens and the Cell Cycle
8.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.3K
