Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glial Cells01:04

Glial Cells

75.3K
Overview
75.3K
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

42
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
42

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Curvulinic Acid-Gregatin Hybrids with Anti-inflammatory Activity from a Soil-Derived Fungus <i>Penicillium</i> sp. KYS-21.

Journal of natural products·2026
Same author

Oxygen-mediated tandem polyethylene upcycling for selective aromatic synthesis.

National science review·2026
Same author

Lattice-Engineered Dual-Electron-Drive Electrode for Selective Ammonia Production From Nitrate.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

AIE-Active Fluorescence "Turn-on" Bioprobes Mediated by Intramolecular Hydrogen-Bonding for Sensitive Detection of H<sub>2</sub>S and Visualization in U87 Cells.

Luminescence : the journal of biological and chemical luminescence·2026
Same author

The Association Between Serum Vitamin D and Lipid Levels in Patients With Depression: A Cross-Sectional Study.

Alpha psychiatry·2026
Same author

Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation.

Journal of neuroinflammation·2026

相关实验视频

Updated: May 5, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.5K

一个转录基因资源,用于神经质GABA相关的ASH神经衰老和候选途径.

Umar Al-Sheikh1,2,3,4,5, Hankui Cheng1,3,4,5, Ahmed Abdulsalam Ali Bakrbaldawi3,4,5,6

  • 1Department of Ophthalmology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.

Frontiers in aging neuroscience
|March 11, 2026
PubMed
概括

在C. elegans glia中恢复GABA合成减少了与年龄相关的神经退行. 这项研究揭示了刺信号传递和HSF-1作为关键途径,参与衰老期间的质GABA介导的神经保护.

关键词:
这里是C. elegans.对于GABA来说,这是一个很好的选择.膠質-神經相互作用神经元衰老的神经元衰老转录基因分析的分析.

更多相关视频

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
06:14

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Published on: May 8, 2018

9.3K
Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer&#39;s Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.5K

相关实验视频

Last Updated: May 5, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.5K
Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
06:14

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Published on: May 8, 2018

9.3K
Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer&#39;s Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.5K

科学领域:

  • 神经科学是一个神经科学.
  • 基因组学就是基因组学.
  • 衰老研究研究 衰老研究

背景情况:

  • 神经元衰老与神经退行有关,部分原因是GABA失调.
  • 在C. elegans中恢复特定质细胞 (AMsh) 中的GABA合成可以减轻与年龄有关的神经退行.

研究的目的:

  • 在神经元衰老期间为质GABA调节提供转录基因资源.
  • 为了确定涉及质GABA相关神经保护的分子通路.

主要方法:

  • 从野生类型的GABA缺乏突变体和C. elegans中获救的突变体中获得ASH神经元的RNA测序.
  • 不同基因表达分析 (DESeq2) 和基因组丰富分析 (clusterProfiler).
  • 在年轻虫中的质细胞和神经元细胞之间的转录组比较.

主要成果:

  • 在老年人群中观察到不同的转录特征.
  • 在体救援组中,对体信号通路 (TRA-1/GLI) 的上调和对HSF-1的下调.
  • 识别潜在的质神经与神经元交叉交互机制.

结论:

  • 这项研究为了解质GABA在神经元衰老中的作用提供了宝贵的转录基因资源.
  • 鉴定了刺信号传递和HSF-1作为质GABA相关的神经保护的潜在媒介.
  • 为剖析神经退行症和确定治疗点提供了分子洞察力.