在帕金森病中使用数字评估来表征运动认知关联
Avigail Lithwick Algon1,2, William Saban1,2,3
1Center for Accessible Neuropsychology, Tel Aviv, Israel.
Frontiers in aging neuroscience
|March 11, 2026
概括
远程认知测试有效地评估帕金森病 (PD) 的严重程度,反映了亲身发现. 这些可访问的工具提供了可扩展的解决方案,用于跟踪PD患者的运动和认知衰退.
科学领域:
- 神经学和认知科学 神经学和认知科学
- 生物医学数据科学 生物医学数据科学
- 老年学和衰老研究研究.
背景情况:
- 传统的帕金森病 (PD) 评估面临着可访问性和可扩展性问题.
- 远程认知测试为改善可访问性和减少参与者负担提供了一个解决方案.
- 对于评估PD严重程度的远程认知测量的实用性仍未得到充分探索.
研究的目的:
- 确定远程认知评估是否可以作为PD严重程度的信息指标.
- 来自远程评估的运动认知关联与传统的面对面发现进行比较.
- 建立一个对PD中远程认知措施的解释性和采用性的基准.
主要方法:
- 分析了一大批面对面的数据集 (PPMI,n=1,417) 与认知 (MoCA) 和运动 (MDS-UPDRS III,H&Y) 成绩相关联.
- 在不同地点对152名PD患者进行远程评估 (视频会议MoCA-VC,在线MDS-UPDRS III,H&Y).
- 使用多变量回归来检查疾病阶段 (H&Y) 和认知得分 (MoCA,MoCA-VC) 之间的关系.
主要成果:
- 在面对面 (ρ=-0.17至-0.12) 和远程 (ρ=-0.32至-0.16) 设置中发现了MoCA和运动分数之间的小,负相关性.
- 每个H&Y的一个阶段增加都与0.65点的MoCA下降 (面对面) 和1.16点的MoCA-VC下降 (远程) 相关.
- 远程评估显示了与面对面评估相当的运动认知关联.
结论:
- 远程,基于家庭的认知评估有效地捕捉了帕金森病中的运动认知关系.
- 这些发现支持使用远程认知测量作为PD严重程度的可访问和可扩展指标.
- 远程测试具有很大的潜力,可以在PD研究和临床实践中得到更广泛的应用.
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