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在临床实践中对四个多重过敏原同时测试 (MAST) 系统进行比较评估

Sojin Lee¹, Junhyup Song², Kyung-A Lee¹

¹Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Journal of asthma and allergy

|March 11, 2026

概括

四个自动化多种过敏原同时测试 (MAST) 系统显示出对过敏查的高度一致. SGTi-过敏屏最符合ImmunoCAP结果,而AdvanSure Alloscreen Max108提供了广泛的覆盖范围,指导实验室选择.

科学领域:

* 临床免疫学和过敏诊断.
* 在体外诊断试验的开发和验证.

背景情况:

*多种过敏原同时测试 (MAST) 对于查过敏原特异性免疫球蛋白E是方便且具有成本效益的.
* 韩国有新的自动化MAST分析仪,可扩展过敏原面板,但对比数据有限.

研究的目的:

*评估和比较韩国四个自动化MAST系统的性能.
* 评估不同MAST平台之间的一致性以及ImmunoCAP,一个参考标准.

主要方法:

*对200个疑似过敏疾病患者的残留血清样本进行了回顾性分析.
*对AdvanSure Alloscreen,AdvanSure Alloscreen Max108,SGTi-过敏屏幕和PROTIA过敏Q进行了测试.
*一致率和科恩的卡帕系数计算;不一致的样本用ImmunoCAP重新测试.

主要成果:

* 在四个MAST系统中,总体一致性高 (91-93%) 和实质性到几乎完美的一致性 (κ = 0.67-0.76).
*SGTi-过敏查显示,在不一致的样本中,与ImmunoCAP的一致性最高 (76.39%).
*AdvanSure Alloscreen Max108显示了与其前身AdvanSure Alloscreen的最高一致性.

结论:

*所有评估的MAST系统都表现出相当大或接近完美的质量一致.
* SGTi-过敏屏幕与黄金标准ImmunoCAP提供了卓越的一致性.
*AdvanSure Alloscreen Max108提供了性能和过敏原覆盖的平衡,建议选择应与实验室需求保持一致.

关键词:

这是一个巨.特定于过敏原的IgE.过敏原过敏原过敏原自动化分析仪自动化分析仪过敏性过敏性过敏性免疫测试是一种免疫测试.免疫球体蛋白E 免疫球体蛋白E 多种过敏原同时测试试验.

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