骨质强度指数:加勒比地区种族/种族差异 西班牙裔,非西班牙裔白人和非西班牙裔黑人美国老年人
Luis Ortiz Vasquez1, Carmen Germosen1, Isabella Rosillo1
1Division of Endocrinology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, United States.
JBMR plus
|March 11, 2026
概括
骨质强度指数 (BMSi) 在加勒比海西班牙裔,非西班牙裔黑人和非西班牙裔白人之间没有差异. 这表明,与区域性骨硬化不同,骨材特性不能解释骨折风险的种族差异.
科学领域:
- 整形外科 整形外科 整形外科
- 骨生物学 骨生物学 骨生物学
- 老年学是一门学科.
背景情况:
- 骨折风险的种族差异仍然存在,尽管考虑了面积骨矿物质密度 (aBMD).
- 用DXA测量的aBMD无法捕捉骨材质的特性,这可能会影响骨折风险.
- 有限的研究存在于骨材特性中的种族/种族差异,特别是包括西班牙裔人口.
研究的目的:
- 在加勒比海西班牙裔 (CH),非西班牙裔黑人 (NHB) 和非西班牙裔白人 (NHW) 个人中调查骨质强度指数 (BMSi) 的种族/种族差异.
- 确定BMSi是否有助于解释骨折风险中的种族/民族差异.
主要方法:
- 利用冲击微印记测量了华盛顿高地因伍德社区衰老项目参与者的BMSi (N=148).
- 跨种族/族群 (CH,NHB,NHW) 的比较BMSi.
- 对年龄,性别,BMI,骨折状况,糖尿病,酒精消耗,吸烟和骨质疏松症治疗进行调整的分析.
主要成果:
- 在CH,NHB和NHW参与者之间没有观察到BMSi的显著差异 (p > 0.22).
- 在调整多个共同变量 (p > 0.47) 后,这些发现保持一致.
- 在BMSi方面,没有发现种族和糖尿病状况之间的显著相互作用.
结论:
- 衡量骨材强度的BMSi在加勒比海西班牙裔,非西班牙裔黑人和非西班牙裔白人中是相似的.
- 根据BMSi的评估,骨质强度的差异似乎无法解释骨折风险的已确定的种族/民族差异.
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