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Updated: Mar 12, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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在类风湿性关节炎中,骨细胞通过p38-MAPK-CREB通路调节骨质保护素的表达

Keitaro Yasumoto1, Toshifumi Fujiwara1, Toshiaki Sugita1

  • 1Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.

JBMR plus
|March 11, 2026
PubMed
概括

类风湿性关节炎 (RA) 会增加骨中的骨质保护素 (OPG). 瘤坏死因子-α (TNF-α) 通过p38-MAPK和CREB信号增强OPG,影响RA骨损失中的骨质细胞活性.

关键词:
克里布 (Creb) 是一个非常重要的数字.这就是TNF-α.骨头改造 骨头改造 骨头改造炎症性骨损失导致的骨质细胞骨质细胞骨质保护剂中的骨质保护剂p38 MAPK信号传输的使用类风湿性关节炎 类风湿性关节炎

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