在生育年龄的男性中,尿路抗生素暴露与血压参数之间的关联:在中国进行的一项基于生物监测的截面研究
Qunshan Shen1,2,3,4, Rui Wang5, Hang Li1
1Reproductive Medicine Center, Human Sperm Bank, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Translational andrology and urology
|March 11, 2026
概括
包括混合物在内的尿路抗生素暴露与生殖年龄男性的高血压有关. 这项研究强调了与常见抗生素残留物相关的潜在健康风险.
科学领域:
- 环境健康 环境健康
- 临床化学 临床化学
- 流行病学 流行病学
背景情况:
- 有限的流行病学数据存在于生殖年龄男性的尿路抗生素负载和血压 (BP).
- 生物监测通常评估一般人群的抗生素暴露,而不是特定的BP相关性.
研究的目的:
- 调查尿路抗生素暴露与生殖年龄男性血压参数之间的关系.
- 探索个人和混合抗生素暴露和BP之间的关联.
主要方法:
- 对967名健康的中国男性 (20-40岁) 进行横截面研究.
- 测量了42个尿液抗生素度,使用高液体染色学-并联质谱法.
- 评估BP参数 (SBP,DBP,PP,MAP) 并使用通用线性模型和基于量子的g计算分析关联.
主要成果:
- 98.9%的参与者有可检测的抗生素,主要是多西环素,红素,西普罗夫洛克萨和佛罗芬尼科尔.
- 在尿道多克西环素,西普罗夫洛克萨,佛罗芬尼科尔和BP参数 (SBP,DBP,PP,MAP) 之间发现了积极的相关性.
- 抗生素混合物与高血压有关,而西普洛克萨显示出最重要的贡献.
结论:
- 个人和混合的尿路抗生素暴露与男性的血压参数有关.
- 尿液中的抗生素残留物可能会影响生殖年龄的男性的心血管健康.
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