系统性炎症和压力尿失禁总指数之间的积极关系:全国横截面分析
Xiaozhi Xia1, Dingbang Liu1, Wei Wang1
1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Translational andrology and urology
|March 11, 2026
概括
系统性炎症总指数 (AISI) 的升高与美国成年人压力尿失禁 (SUI) 风险的增加有关. 这一发现表明炎症可能在SUI的发展和进展中发挥作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 炎症研究 炎症研究
- 公共卫生 公共卫生
背景情况:
- 压力尿失禁 (SUI) 是一种普遍的盆底疾病,其特征是不自发的尿泄漏.
- 系统性炎症综合指数 (AISI) 是一种新开发的系统性炎症标志物.
- AISI和SUI之间的关联没有得到广泛的研究.
研究的目的:
- 在美国成年人代表性样本中调查AISI和SUI之间的关系.
- 为了确定是否升高的全身炎症与SUI的更高患病率有关.
主要方法:
- 利用了2007-2016年国家健康和营养检查调查 (NHANES) 中10,934名参与者的数据.
- 通过自我报告问卷来评估SUI状态,并根据血清数据计算AISI.
- 使用加权多变量后勤回归来分析AISI和SUI之间的关联.
主要成果:
- 更高的AISI水平与更高的SUI频率相关.
- 与最低四分位数相比,在最高AISI四分位数中的个体显著增加了SUI的几率 (OR=1.34,P=0.01).
- 在子组分析中,没有发现AISI与其他共变量之间的显著相互作用.
结论:
- 在美国成年人中,高AISI与SUI独立相关.
- 在未来的SUI研究中,AISI可能会成为一个有价值的复合性炎症标记物.
- 进一步调查系统性炎症在SUI中的作用是有必要的.
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