对I型胃神经内分泌瘤进行内镜治疗后的进展:单中心回顾性研究
Ze-Liang Yang1, Hui-Ke Wang2, Yong Liu1
1Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
World journal of gastroenterology
|March 11, 2026
概括
将内镜治疗与体静止素类似物 (SSA) 结合起来,可以有效地管理胃神经内分泌瘤 (G-NETs). 高的中性粒细胞与淋巴细胞比率 (NLR) 表明进展风险增加,而SSAs降低了这一风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 内镜治疗是I型胃神经内分泌瘤 (G-NETs) 的标准.
- 这种方法可能无法完全解决瘤发病症,导致潜在的进展.
- 识别风险因素对于有效的G-NET管理至关重要.
研究的目的:
- 评估内镜治疗I型G-NETs的疗效.
- 确定影响G-NET进展的关键预后因素.
- 评估体静止素类似物 (SSA) 和中性粒细胞与淋巴细胞比率 (NLR) 在G-NET结果中的作用.
主要方法:
- 对128名I型G-NET患者 (2009-2024) 的回顾性分析.
- 患者被分为非进展性 (n=87) 和进展性 (n=41) 队列.
- 用单变量,多变量考克斯回归和卡普兰-梅尔分析来确定预后变量.
主要成果:
- 内镜治疗加上辅助性SSAs显著降低了进展风险 (HR=0.38,P=0.027).
- 中性粒细胞与淋巴细胞比率 (NLR) ≥2与进展风险增加有关 (HR=2.14,P=0.030).
- 证实NLR和SSA使用是独立的预后因素.
结论:
- 用SSA进行内镜治疗的组合疗法对I型G-NETs有效.
- SSA和NLR是G-NET复发的重要预后因素.
- 这些因素可以指导治疗策略,以改善患者的治疗结果.
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