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在耐卡巴胺的肠道细菌中,Cefiderocol 敏感性和 Carbapenemase 概况

Ayça Bayrak¹, Alper Akçalı¹, Reyhan Mutlu²

¹Department of Medical Microbiology, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Türkiye.

Infectious diseases & clinical microbiology

|March 11, 2026

概括

在土耳其,Cefiderocol对抗卡巴耐药的肠道细菌 (CRE) 具有很高的敏感性. 产生OXA-48的CRE分离物比产生MBL的Cefiderocol更容易受到Cefiderocol的影响,这表明其作为最后手段治疗的潜力.

科学领域:

临床微生物学临床微生物学
传染病传染病传染病
抗微生物耐药性抗微生物耐药性

背景情况:

耐卡巴胺肠道细菌 (CRE) 是一个重大的公共卫生威胁.
塞菲德罗科尔是CRE感染的最后避难所抗生素.

研究的目的:

为了确定来自土耳其西马拉拉地区的CRE分离物中塞菲德罗科尔的敏感性.
为了评估 cefiderocol 易感性和 carbapenemase 类型之间的联系.

主要方法:

在120个CRE分离体上进行了磁盘扩散和MIC测试.
使用组合磁盘方法确定了碳烯酶基因 (KPC,OXA-48,MBL,AmpC).

主要成果:

在Cefiderocol的敏感性为92.5% (EUCAST) 和99% (CLSI).
在KPC,OXA-48和MBL的患病率分别为48.9%,31.6%和16.3%.
对KPC的敏感率为90%,对OXA-48的敏感率为100%,对MBL生产者的敏感率为75%.

结论:

生产CRE分离物的OXA-48显示出比MBL生产者更高的对 cefiderocol的敏感性.
在土耳其,Cefiderocol是CRE感染的潜在治疗选择.

关键词:

这就是Cefiderocol.进入细菌体中的细菌.抗微生物耐药性抗微生物耐药性

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