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在肺移植后绘制未知原因的急性肺全移植功能障碍:从临床和放射学模式的见解

Marco Guerrieri¹, Matteo Fanetti¹, Felice Perillo¹

¹Respiratory Diseases Unit, University Hospital of Siena, Siena, Italy.

|March 11, 2026

概括

异常性急性肺异位移植功能障碍 (i-ALAD) 是肺移植后的常见,可逆并发症. 高分辨率CT扫描显示出不同的特征,可以帮助识别i-ALAD并预测疾病进展.

科学领域:

肺部病理学肺部病理学
移植手术移植手术
放射学放射学是一门学科.

背景情况:

急性肺异位移植功能障碍 (ALAD) 是肺移植后的一种新定义的临床问题,其特征是急性移植功能障碍.
异常性ALAD (i-ALAD) 指的是没有明确可识别的原因的ALAD.

研究的目的:

描述i-ALAD的临床和放射性特征.
探索i-ALAD.中的高分辨率计算机断层扫描 (HRCT) 发现.
为了比较i-ALAD成像特征与急性细胞排斥 (ACR).

主要方法:

对497名肺移植接受者进行支气管镜检查的回顾性分析.
在2013年至2024年期间,确定了20个i-ALAD病例.
对临床数据和HRCT发现的评估,与ACR病例进行比较.

主要成果:

i-ALAD发生在12.4%的接受者身上 (20/158).
大多数i-ALAD病例是可逆的,但有些病例进展为慢性肺异位移植功能障碍 (CLAD).
HRCT通常显示支气管壁加厚,分球间隔膜加厚和肺微块;i-ALAD比ACR有更多的支气管切开,空气捕获和多溢出.

结论:

i-ALAD是一种常见的,潜在的可逆性肺移植后并发症.
独特的HRCT特征可能有助于i-ALAD识别和CLAD风险分层.
需要进一步的多中心研究来验证这些发现,并完善i-ALAD的表征.

关键词:

急性肺异位移植功能障碍急性肺异位移植功能障碍后续行动后续行动高分辨率的胸部CT CT.肺移植是什么意思?肺移植是什么意思移植后并发症移植后并发症

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