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双功能口服纳米疗法通过向炎症和纤维化通路来缓解败血症类多器官衰竭

James Asenso^1,2,3, Neha Choudhury^1,2,3, Raghu Ganugula^1,2,3,4

¹The Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, 35401, United States.

Bioactive materials

|March 11, 2026

概括

一种新的口服纳米粒子疗法通过减少炎症和预防器官损伤,有效地对抗败血症. 这一突破为因败血症引起的多器官衰竭提供了有前途的新疗法.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

败血症是一种导致多器官衰竭的严重疾病,治疗选择有限.
纳灵宁 (NAR) 具有治疗潜力,但其口服生物可用性较差.
针对肠道叶酸受体提供了一种改善口服药物递送的策略.

研究的目的:

为了研究双重功能纳米粒子 (P2Ns-NAR) 在口腔败血症治疗中的有效性.
评估纳米颗粒能够准肠道叶酸受体并输送纳灵宁的能力.
评估P2Ns-NAR在脂多糖诱导性败血症小鼠模型中的治疗效果.

主要方法:

使用纳灵 (NAR) 开发一种双功能的纳米粒子 (P2Ns-NAR).
在脂多糖诱导性败血症的小鼠模型中服用口服纳米颗粒配方.
基因表达的分析 (促炎性,亡性,纤维化,炎症体标志物) 和组织学检查.

主要成果:

显著降低mRNA表达的促炎性,光性,纤维化和炎症相关的标志物.
预防多个器官的组织损伤,包括肺,肝脏,脏,心脏,大脑,肠道和脏.
肺部,肝脏,脏和心脏中的原沉积 (纤维化) 显著减少.

结论:

双功能纳米粒子平台 (P2Ns-NAR) 证明了作为治疗败血症的口服疗法的高效性.
这种新型配方通过减轻炎症和纤维化,有效地预防多器官衰竭.
P2Ns-NAR代表了治疗败血症的口服治疗策略的有前途的进展.

关键词:

免疫调节是一种免疫调节.多器官衰竭是多个器官的衰竭.在Naringenin,我们可以看到.口服纳米颗粒的使用方法败血症这是一种败血症.

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