相关实验视频

Updated: Mar 12, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

肝细胞癌中的瘤疫苗:进步,挑战和通往精确免疫疗法的道路

Bin Niu^1,2, Jun Xu³, Liaoyun Zhang¹

¹Department of Infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Journal of clinical and translational hepatology

|March 11, 2026

概括

肝细胞癌 (HCC) 治疗对于晚期病例是有限的. 瘤疫苗有望激活免疫系统对抗癌症,目前正在研究个性化方法和组合疗法,以改善患者的治疗结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
晚期HCC的治愈治疗选择仍然有限.
癌症免疫疗法,特别是瘤疫苗,提供了一种有希望的策略,可以激活宿主免疫系统对抗癌细胞.

研究的目的:

系统地审查目前基于瘤疫苗的免疫疗法对HCC的进展.
专注于疫苗平台,向抗原,临床试验结果和临床翻译的挑战.
探索个性化医学和多模式治疗策略在改善HCC预后方面的潜力.

主要方法:

关于HCC瘤疫苗的现有文献的审查.
对各种疫苗平台 (,树突细胞,核酸,病毒载体) 的分析.
检查临床试验数据,安全性和免疫性概况.

主要成果:

基于体和树突细胞的疫苗具有最广泛的临床数据,显示出良好的安全性和免疫性.
针对瘤特异性抗原的个性化疫苗正在改进疫苗设计.
挑战包括瘤免疫微环境抑制,异质性,免疫逃脱和有限的免疫性.

结论:

尽管存在挑战,但针对HCC的基于疫苗的免疫疗法具有显著的潜力.
与个性化医疗和多模式疗法的整合可能会改善患者的长期结果.
需要进一步的研究来克服临床翻译标准化,生产和监管监管方面的障碍.

关键词:

临床试验临床试验是指临床试验的临床试验.肝细胞癌是肝细胞癌.个性化治疗癌症疫苗个性化治疗癌症疫苗治疗方法治疗方法瘤的免疫微环境这是瘤疫苗.

更多相关视频

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...