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通过基于利博醇的GalNAc合物增强向肝脏的输送

Sai Pallavi Pradeep1, Ruchi Ruchi1, Raman Bahal1

  • 1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.

Molecular therapy. Nucleic acids
|March 11, 2026
PubMed
概括

对GalNAc的微小几何变化增强了siRNA的稳定性和传递. 这种修改后的N-乙甲胺 (GalNAc) 支架通过改善药物暴露和安全性,对治疗肝脏疾病充满希望.

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