血清HMGB1作为儿科败血症休克的生物标志物和预测模型:一个队列研究
Bingxin Wang1, Xue Liu1, Keke Ma1
1Department of Pediatrics, Xinxiang Medical University First Affiliated Hospital, Weihui, China.
Translational pediatrics
|March 11, 2026
概括
高流动性组盒子1 (HMGB1) 显示作为儿科败血症的生物标志物具有前途. 在名图模型中将HMGB1与前素 (PCT) 结合起来,可以准确预测儿童的败血性休克风险.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 发现生物标志物的发现.
- 败血症的研究研究.
背景情况:
- 败血症是儿童死亡的主要原因之一.
- 高流动性组盒子1 (HMGB1) 是成人败血症的潜在预后生物标志物.
- 在儿科败血症中HMGB1的实用性需要进一步调查.
研究的目的:
- 评估HMGB1作为儿科败血症休克的预后生物标志物.
- 开发儿童感染性休克的临床预测模型.
主要方法:
- 对46名患有败血症的儿科患者进行前性队列研究.
- 在入院后24小时内测量出的血清HMGB1水平.
- 接收器操作特征 (ROC) 曲线分析和多变量逻辑回归用于开发名ogram模型.
主要成果:
- 37%的患者发生了败血性休克.
- 升高的HMGB1,甲素 (PCT),血清粉样蛋白A (SAA) 和素-6 (IL-6) 水平与休克有关.
- 确定HMGB1和PCT是独立的风险因素.
- 将HMGB1和PCT结合在一起的诺莫格拉姆模型实现了高分辨率 (AUC 0.874).
结论:
- 血清HMGB1,特别是结合PCT,准确地预测了儿科败血症的败血症休克风险.
- 诺莫格拉姆模型为风险分层提供了一个实用的床头工具.
- 建议对模型进行外部验证.
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