肝功能指标作为患儿代谢 (功能障碍) 相关脂肪肝疾病的风险因素:系统性审查和元分析
Xiaojiao Fan1, Fang Cheng1,2, Hongyun Zhou1
1Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Translational pediatrics
|March 11, 2026
概括
像ALT和GGT这样的肝功能指标与儿童的代谢功能障碍相关的脂肪肝疾病 (MAFLD) 风险有关. 高水平的ALT,胆固醇,甘油三,LDL和降低的HDL是儿科MAFLD的潜在危险因素.
科学领域:
- 儿科 儿科 儿科
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢 (功能障碍) 相关的脂肪肝疾病 (MAFLD) 是儿童和青少年日益关注的问题,与肥胖流行病有关.
- 目前关于使用肝功能指标用于儿科MAFLD查的证据是不一致的,因为研究设计和人群不同.
研究的目的:
- 进行系统性审查和元分析,以评估肝功能指标作为儿童群体中MAFLD的风险因素.
- 综合全球证据以澄清肝功能指标与儿童和青少年的MAFLD之间的关联.
主要方法:
- 从四个主要数据库 (Cochrane Library,Embase,Web of Science,PubMed) 进行观测研究的系统审查和元分析,截至2025年7月5日.
- 纳入标准集中在儿童 (18岁以下) 中,将异常和正常肝功能指标组之间的MAFLD风险进行比较.
- 几率比率 (OR) 和95%置信区间 (CI) 使用R中的"元"包计算,并对异质性和出版偏差进行评估.
主要成果:
- 该分析包括27项研究,其中包括3,237例MAFLD病例.
- 氨氨基转移酶 (ALT) [OR: 1.15 (1.01, 1.30) ],马-氨基转移酶 (GGT) [OR: 1.30 (1.09, 1.56) ]和高密度脂蛋白 (HDL) [OR: 0.97 (0.96, 0.98) ]的升高与MAFLD风险相关.
- 确定的特定危险因素包括ALT升高,总胆固醇,甘油三,LDL和HDL降低,显著的ORs从2.39到178.09.
结论:
- 肝功能指标显示了儿童和青少年早期MAFLD查的潜力.
- 局限性包括少数研究,潜在的异质性和观察设计中固有的偏差.
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