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成年人良性过渡性高酸血症:病例报告和文献综述

Jose L Rodriguez Castro¹, Grettel Gonzalez Garcia², Daniel Heller^1,3

¹HCA Florida Aventura Hospital, Aventura, Florida.

HCA healthcare journal of medicine

|March 11, 2026

概括

良性过渡性高酸酶血症 (BTH) 是一种罕见的疾病,导致暂时高酸酸酶 (ALP) 水平,通常在儿童中. 这一案例突出了一个罕见的成年人呈现,强调了需要提高成年人的意识和诊断考虑.

科学领域:

内分泌学在内分泌学.
临床生物化学临床生物化学

背景情况:

良性过渡性高酸血症 (BTH) 的特点是血清酸酸酶 (ALP) 暂时升高,没有潜在的肝脏或骨疾病.
虽然在儿童中常见,但BTH在成年人中很少被报告,关于其表现和病理生理学的数据有限.
BTH的确切原因尚不清楚,但怀疑是病毒感染,ALP异酶的改变化可能会降低干净度.

研究的目的:

在成年患者中报告一种罕见的良性过渡性高酸血症病例.
讨论成人BTH呈现的诊断挑战和影响.

主要方法:

一个案例介绍了一名62岁的女性,偶然发现ALP水平升高.
进行了全面的实验室测试,包括肝功能测试,骨标记物和瘤标记物.
进行了成像研究,包括腹部超声波和CT扫描,以及骨检查.
性酸酶异酶电泳被用来描述ALP的升高.

主要成果:

患者呈现明显升高的ALP (1496U/L),但没有肝脏或骨疾病的证据.
所有其他实验室测试,包括脂酶,甲状腺功能,副甲状腺激素,维生素D,电解质和瘤标志物,都在正常范围内.
图像学研究没有发现肝脏或骨异常.
ALP电泳揭示了肝脏和骨异酶的升高,与BTH.一致.
在8周内,ALP水平正常化.

结论:

良性过渡性高酸血症在成年人中异常罕见,由于文献有限,这给诊断带来了挑战.
这一案例凸显了在患有单独ALP升高的成年患者中考虑BTH的重要性,即使没有典型的儿科风险因素.
在成年人中早期诊断BTH可以防止不必要的调查和相关的医疗费用.

关键词:

BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH BTH B 性酸酶是一种性性酸酶.性酸酶/血液中的性酸酶良性过渡性高酸盐血症是什么血液中的蛋白质电泳.案例报告案例报告过高酸盐血症的发生.

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