唇部小唾液腺活检是否保持了对Sjögren病的诊断敏感性和特异性 - - 一项机构研究
Vijayanirmala Subramani1, Malathi Narasimhan1, Sharada T Rajan1
1Department of Oral Pathology, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
International journal of applied & basic medical research
|March 11, 2026
概括
唇部小唾液腺活检 (LMSGB) 显示诊断Sjögren的准确性很低.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 组织病理学 组织病理学
背景情况:
- 目前美国风湿学会/欧洲抗风湿联盟 (ACR-EULAR) 的指导方针使用唇部小唾液腺活检 (LMSGB) 的焦点得分 (FS) 来诊断Sjögren病 (SjD).
- 有限的研究评估了LMSGB的诊断灵敏度和特异性,以及对SjD的血清学测试.
- 关于FS和血清学测试在SjD诊断中的关联,存在相互矛盾的证据.
研究的目的:
- 根据目前ACR/EULAR对疑似Sjögren病 (SjD) 患者的建议,确定LMSGB的诊断灵敏度和特异性.
主要方法:
- 包括怀疑SjD症状 (口腔/眼睛干燥,腺外症状) 接受LMSGB的患者.
- 分析包括活检样本的充分性,焦点得分 (FS),病理学家的解释和生物化学分析来诊断SjD.
- 评估了LMSGB的诊断准确性,敏感性和特异性.
主要成果:
- 该研究发现LMSGB的阳性和阴性预测值较低,这表明SjD活检结果预测效果有限.
- LMSGB的整体诊断准确率为40.54%,表明在区分患有SjD和没有SjD的患者方面无效.
- 负的LMSGB结果并不能排除SjD,但可以排除其他入性异口症的原因.
结论:
- 唇部小唾液腺活检 (LMSGB) 对Sjögren病 (SjD) 有显著的诊断限制.
- 虽然负的LMSGB并不排除SjD,但它可以排除口腔干燥的其他原因.
- 需要进一步的研究来改善SjD的诊断策略.
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