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烟与印度女性乳腺癌风险的关联:一个多中心病例控制研究
Romi Moirangthem1,2, Ankita Manjrekar1, Gayathri B Pullat1,2
1Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India, tmc.gov.in.
International journal of breast cancer
|March 11, 2026
概括
烟使用与女性患乳腺癌 (BC) 的风险更高有关. 早期和长期使用,特别是在第一次满期怀孕之前,会显著增加这种风险.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 乳腺癌 (BC) 是全球女性的主要癌症.
- 烟对BC发育的具体影响仍未得到充分研究.
- 这项研究调查了烟和BC风险之间的关联.
研究的目的:
- 评估烟消费与乳腺癌发病率之间的关联.
- 为了确定烟的持续时间和开始年龄是否影响BC风险.
- 计算由于烟而导致的BC的可归因分数.
主要方法:
- 一个基于多中心医院的病例控制研究.
- 包括2,553个经组织病理学证实的BC病例和2,239个访客对照.
- 对混因素进行调整后的后勤回归分析;计算了赔率比率 (OR) 和置信区间 (CI).
主要成果:
- 曾经使用烟显示BC风险增加 (OR: 1.19,95% CI: 1.00-1.41).
- 发现与时间 (OR >25年: 1.38,95% CI: 1.04-1.83) 有剂量反应关系.
- 在20岁前和第一个满期怀孕 (FFTP) 之前,观察到更高的风险.
结论:
- 烟草与所有亚型的BC风险增加有关.
- 风险随着持续时间的延长和早期启动而增加,特别是在FFTP之前.
- 建议将无烟烟草纳入烟草控制政策,以减轻BC负担.
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