在消化道瘤中围神经侵入:免疫系统相互作用和治疗策略
Jia-Yu Pang1,2, Rong-Yao Jin1, Han-Xiao Zhang1
1Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
World journal of clinical oncology
|March 11, 2026
概括
在消化系统癌症中,围神经入侵 (PNI) 通过抑制T细胞和极化巨细胞来破坏抗瘤免疫力. 这种免疫失衡促进瘤的进展和转移,突出显示PNI是癌症免疫治疗的目标.
科学领域:
- 胃肠道学和瘤学
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 消化道瘤对全球健康构成重大挑战,患病率和死亡率高.
- 周围神经侵入 (PNI) 是胃肠癌攻击性和预后不佳的关键因素.
- 在这些癌症中,PNI与抗瘤免疫反应之间的相互作用是复杂的,并未完全理解.
研究的目的:
- 系统地审查在胃肠道癌症中PNI和抗瘤免疫之间的复杂关系.
- 分析受PNI影响的关键免疫组件,包括免疫检查点和细胞参与者.
- 阐明PNI如何影响瘤免疫微环境并促进癌症的进展.
主要方法:
- 系统性文献综述,重点关注胃肠道癌症中的PNI和抗瘤免疫力.
- 分析与免疫相关的组件,如编程细胞死亡蛋白1 (PD-1) /编程死亡连接体1 (PD-L1) 轴,T细胞子集和与瘤相关的巨细胞.
- 评估免疫检查点及其在PNI介导免疫调节中的作用.
主要成果:
- 通过PD-1/PD-L1相互作用抑制T细胞活性,PNI破坏免疫平衡.
- PNI扭曲T细胞分化,导致抗瘤功效降低和免疫抑制增加.
- PNI使瘤相关的巨细胞两极分化,促进瘤的进展,并可能有助于转移性行为.
结论:
- 在胃肠道癌症中,PNI显著重塑瘤免疫微环境.
- 了解PNI对免疫力的影响为识别新型免疫治疗点提供了一个框架.
- 针对PNI相关的免疫调节可能为胃肠道癌症提供精确的治疗策略.
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