轻度行为障碍中的冷漠:与皮层厚度和灰质体积的关联
medRxiv : the preprint server for health sciences
|March 11, 2026
概括
轻度行为障碍与冷漠 (MBI-冷漠) 与阿尔茨海默病 (AD) 易受影响的区域的大脑厚度和体积的减少有关. 这些变化表明,在痴呆症发病之前,MBI-无动于衷的个体可能会出现早期的神经退行.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 轻度行为障碍 (MBI) 标志着晚年生活中的行为变化,作为认知衰退和痴呆症的风险标志物.
- 漠不关心,一个关键的MBI症状,涉及到兴趣和主动性的减少,可能是痴呆症的前身,并与大脑结构变化有关.
研究的目的:
- 与没有神经精神症状 (没有NPS) 的人相比,研究MBI-无情的个体的结构性大脑差异.
- 在认知正常 (CN) 和轻度认知障碍 (MCI) 个体中探索MBI-无情和神经解剖学变化之间的关联.
主要方法:
- 利用从国家阿尔茨海默氏症协调中心的446名参与者 (59名MBI冷漠,387名没有NPS) 的数据进行线性回归.
- 分析了区域性大脑测量,包括预定义的阿尔茨海默病感兴趣的元区域 (ROI) 和特定的额头区域中的皮层厚度和灰质体积,并对共变量进行调整并应用FDR校正.
主要成果:
- 在AD元ROI中,MBI无动于衷与下皮层厚度和灰质体积显著相关.
- 患有MBI无情的个体在背侧前额皮质 (dlPFC) 的厚度和体积减少,在轨道前额皮质 (OFC) 的体积减少.
- 这些关联在阿尔茨海默氏症易受影响的地区比通常与痴呆症冷漠相关的地区更强.
结论:
- 在CN和MCI阶段的MBI冷漠可能表明早期的阿尔茨海默病相关的神经退行.
- 在MBI-无情的结构性大脑变化似乎先于那些传统上与痴呆症晚期无情相关的变化.
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