相关实验视频
Updated: Mar 12, 2026

09:11
Cortisol Measurement in Koala Phascolarctos cinereus Fur
Published on: August 23, 2019
11.2K
简化每日皮质醇循环分析:验证和对比皮质醇 sinus 评分与 Cosinor 和 JTK_CYCLE 模型
medRxiv : the preprint server for health sciences
|March 11, 2026
概括
我们开发了皮质醇侧向评分 (CSS),这是评估日常皮质醇模式的新指标. 这种简单的分数准确地反映了皮质醇节律性,有助于在较少样本的情况下进行临床和研究应用.
科学领域:
- 内分泌学 在内分泌学.
- 时间生物学 时间生物学
- 计算生物学 计算生物学
背景情况:
- 每日皮质醇循环,反映下丘脑-垂体-上腺 (HPA) 轴的功能,对健康至关重要.
- 目前分析皮质醇节律的方法产生复杂的数据,阻碍了将其整合到临床和机器学习工作流程中.
- 为了在大规模研究和诊断中实际应用,需要一种简化,单值的指标.
研究的目的:
- 引入和验证皮质醇侧向评分 (CSS),一种新的无模型的标量度量,用于量化每日皮质醇暴露和节律性.
- 评估CSS的表现与已建立的昼夜分析方法相比,以及其在预测健康结果中的实用性.
- 为了确定可靠的CSS计算所需的每日样本的最低数量.
主要方法:
- 开发了皮质醇正弦评分 (CSS),使用与正弦转换的日间时间权重加权的皮质醇测量的加权和.
- 用501名孕妇的3006个唾液样本验证了CSS,每天6个时间点测量皮质醇.
- 将CSS性能与Cosinor回归和JTK_CYCLE进行比较,并评估其与社会劣势和肠道微生物组合的关联.
主要成果:
- CSS有效量化了每天的皮质醇暴露,区分了早晨占主导地位的,晚上转移的和平坦的节奏.
- 从已确定的方法 (AUC=0.89) 中,CSS显示出与振幅和缩的强烈相关性,并捕获了与社会不利状况的已知关联.
- CSS 保持高精度,每天只需 3-4 个样本,其中 06:00 时间点是必不可少的.
结论:
- 皮质醇侧面评分 (CSS) 提供了一种简单,可解释和可靠的日常皮质醇循环测量方法,适合大规模流行病学研究和临床查.
- CSS简化了复杂的昼夜数据,促进了整合到统计模型,临床工作流程和ML/AI管道中.
- 使用CSS减少采样协议 (3-4分) 保持分析完整性,减少参与者负担,并通过开源R包实现皮质醇节律分析的民主化.
相关概念视频
Correlation between ECG and Cardiac Cycle
14.0K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
14.0K
Calibration Curves: Correlation Coefficient
5.2K
In a linear calibration curve, there is a value called the calibration coefficient, denoted by 'r,' which measures the strength and the direction of association between two variables. The correlation coefficient value ranges from −1 to +1. A value of +1 indicates a perfect positive linear correlation, −1 denotes a perfect negative correlation, and 0 implies no correlation between the two variables. A positive correlation value establishes that as one variable increases, the...
5.2K
Kendall's Coefficient of Concordance
1.1K
Kendall's Coefficient of Concordance (W), also known as Kendall's W, is a non-parametric statistical measure used to assess the agreement or concordance between multiple raters or judges when they rank a set of items. It is often used when you have ordinal data (ranks) and you want to see if there is consistency or consensus among the raters. It is widely applied in research areas such as psychology, medicine, and social sciences, where multiple judges are asked to rank or rate subjects...
1.1K
Calculating and Interpreting the Linear Correlation Coefficient
8.4K
The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable, x, and the dependent variable, y. Hence, it is also known as the Pearson product-moment correlation coefficient. It can be calculated using the following equation:
8.4K
z Scores and Area Under the Curve
19.9K
z scores are the standardized values obtained after converting a normal distribution into a standard normal distribution. A z score is measured in units of the standard deviation. The z score tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a z score of...
19.9K
Exercise Stress Test
1.7K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
1.7K

