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糖尿病和肥胖症降低了MASLD转介途径中的FIB-4精度
Abdel-Aziz Shaheen1,2, Elizabeth Baguley1,2, Mark G Swain1
1Division of Gastroenterology and Hepatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
FIB-4评分低于选的患者与代谢功能障碍相关的脂肪性肝病 (MASLD) 患有糖尿病或肥胖. 这些人需要更快的弹性体检评估,即使FIB-4得分低,以改善MASLD风险分层.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 评估非侵入性肝病的评估.
- 生物标志物绩效评估的评估
背景情况:
- 初级保健使用FIB-4指数进行代谢功能障碍相关的脂肪性肝病 (MASLD) 选.
- FIB-4准确度可能会受到患者特征的影响,例如糖尿病和肥胖.
研究的目的:
- 评估FIB-4性能与MASLD中的弹性学相比.
- 将FIB-4与其他非侵入性测试进行比较.
- 通过BMI,糖尿病,性别,ALT和年龄来评估影响的改变.
- 校准 2D-SWE 和 VCTE 的值.
主要方法:
- 分析了两个队列 (卡尔加里:2D-SWE,N=8,126;埃德蒙顿:VCTE,N=985) 与配对的血清分数和弹性图.
- 使用超值概率将2D-SWE与VCTE切线对齐.
主要成果:
- 在70-77%的患者中观察到FIB-4<1.30.
- 糖尿病或BMI≥30kg/m2的个体在FIB-4的1.30时,肝硬度≥8kPa的概率更高.
- 体重指数和糖尿病在给定的FIB-4时显著增加了肝硬度的概率.
结论:
- 单独使用FIB-4就不足以对患有糖尿病和/或肥胖的MASLD患者进行选.
- 这些患者甚至在FIB-4<1.30.30的情况下也需要加速弹性体检.
- 为了改善MASLD风险分层,需要完善的转诊途径,包括患者特征.
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