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针对性微波切除局部前列腺癌 (VIOLETTE试验):一个前性的多中心研究

Nicolas Barry Delongchamps¹, Alexandre Peltier², Eric Potiron³

¹Department of Urology, Hôpital Cochin, APHP, Université Paris Cité, Paris, France.

BJU international

|March 11, 2026

概括

向微波除 (TMA) 是中等风险前列腺癌 (PCa) 的安全有效的焦点治疗方法. VIOLETTE试验发现,81%的患者在12个月后没有临床显著的PCa.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科
医疗技术医疗技术医学技术

背景情况:

中期风险前列腺癌 (PCa) 需要有效的焦点治疗选择.
基于器官的追踪 (OBT) 融合技术为最小侵入性手术提供了精确的指导.

研究的目的:

评估使用OBT Fusion对中等风险PCa进行向微波切除 (TMA) 的瘤结果.
评估这种焦点治疗方法的安全性和功能结果.

主要方法:

未来的第二阶段,多中心欧洲研究 (VIOLETTE试验).
入学男性中等风险PCa (PSA<20 ng/mL,单次MRI可见损伤≤15 mm,ISUP等级组2).
使用OBT融合指导 (跨或跨直肠) 进行的TMA.

主要成果:

在12个月内81%的实地临床显著PCa (csPCa) 免费率.
三名患者发生了五次严重不良事件;尿功能稳定,性功能和射精功能下降.
只有5.2%的患者需要进行激进治疗.

结论:

与OBT融合的TMA是局部中等风险PCa的安全有效的焦点疗法.
VIOLETTE试验满足了其主要终点,在预防现场cspca复发方面表现出高疗效.

关键词:

焦点治疗焦点治疗图像融合图像融合图像融合微波除是微波除的一种方法.基于器官的追踪方式前列腺癌是前列腺癌.通过经经.

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