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Updated: Mar 12, 2026

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
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探索线粒体功能障碍对的因果影响:孟德尔的随机化研究

Lin-Ming Zhang1, Fei Wang2, Bing-Ran Zhang3

  • 1Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
|March 11, 2026
PubMed
概括

研究人员确定了三种关键基因 - - 基因酸酸酶 (HAGH),氧结合蛋白相关蛋白1A (OSBPL1A) 和酸酶2 (PANK2) - - 作为的关键驱动因素. 这些基因将线粒体功能障碍与神经炎症和亡联系起来,提供新的治疗点.

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