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在患有轻度自主皮质醇分泌的患者中评估帕奇科罗伊德光谱
Elif Kiliç Kan1, Emrah Kan2, Bilge Eraydin3
1Department of Endocrinology and Metabolism, Faculty of Medicine, Ondokuz Mayis University, Atakum, Samsun, Turkey.
Arquivos brasileiros de oftalmologia
|March 11, 2026
概括
患有轻度自主皮质醇分泌的患者表现出 subfoveal 冠状腺厚度增加和更高的 pachychoroidal 频谱疾病率. 这些发现突出了与这种内分泌条件相关的潜在眼部变化.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 轻度自主皮质醇分泌 (MACS) 与各种系统性影响有关.
- 在MACS中的眼部结构和血管变化尚未得到充分理解.
- 增强的深度成像光学连贯性断层扫描 (EDI-OCT) 和OCT血管造影 (OCTA) 提供了详细的冠状腺可视化.
研究的目的:
- 为了研究患有MACS的患者的冠状腺结构和血管变化.
- 为了比较MACS患者的眼部发现与那些有非功能性腺瘤的患者.
- 为了与MACS中的临床特征相关联,将亚叶冠状腺厚度与临床特征相关联.
主要方法:
- 横截面研究比较30名MACS患者与30名对照人群 (非功能性腺瘤).
- 通过使用光谱域OCT,评估了亚状胆道厚度 (SFCT),包胆道频谱疾病 (PSD) 和胆道血管度指数 (CVI).
- 分析了SFCT和临床参数之间的群体差异和相关性.
主要成果:
- 在MACS患者中,SFCT (355微米对297微米,p=0.014) 和PSD频率 (68.3%对31.7%,p<0.001) 显著更高.
- 在MACS患者中,神器较为常见 (71.4%与42.9%,p=0.002).
- CVI在两组之间是可比的 (p=0.072);SFCT与轴长,球形等效,皮质醇水平和疾病持续时间相关.
结论:
- 与对照组相比,MACS患者的SFCT增加和PSD患病率更高.
- 流体和血管结构的改变是相对相似的.
- 眼部变化可能与自主皮质醇分泌有关.
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