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使用血管塑造气球导管扩展尼丁醇线圈的分析

Zakiyyah Auchoybur¹, Aiden O'Loughlin², Sharath Sriram¹

¹RMIT University, Melbourne, VIC, Australia.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

|March 11, 2026

概括

一种新的导管气球装置与尼丁醇线圈元素显示了有希望的针对性动脉药物输送. 分析了几何约束,以优化线圈设计,以有效地回归斑块和预防心血管事件.

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
材料科学材料科学材料科学

背景情况:

易受伤害的斑块破裂会导致心脏病发作和中风.
目前的治疗方法缺乏有效的动脉药物递送装置.
需要一种新的设备来直接,高效和有效地输送动脉壁药物.

研究的目的:

提出和分析一种新的药物输送装置.
为了确定与导管气球相合的尼丁醇线圈元件的最佳几何约束.
为了评估设备在模拟生理条件下的性能.

主要方法:

对于线圈几何学优化的有限元分析 (FEA).
导管气球充气模型的开发和验证.
用不同的线圈设计对气球充气的实验验证.

主要成果:

气球变形随着电线直径和线圈旋转而增加.
观察到线圈缩短,类似于支架扩张.
确定了最佳的线圈设计:用≤0.18mm线的0.5-3转,或用>0.18mm线的0.5转.

结论:

新型尼丁醇线圈导管气球装置显示了针对性动脉药物输送的潜力.
设备设计必须考虑到线圈缩短.
较小的线径在灵活性和导航方面提供了临床优势.

关键词:

动脉样硬化动脉样硬化气球血管整形术气球血管整形术药物输送是药物输送的过程.有限元分析是有限元分析.医疗器械医疗器械医疗器械尼丁醇是一种尼丁醇.易受伤害的斑块是易受伤害的

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