系统性药物与芬兰50岁以上成年人手术治疗白内障有关
Antti Riikonen1, Jari Haukka2, Tuomas Lilius3,4,5
1Unit of Vitreoretinal Surgery, Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.
Acta ophthalmologica
|March 11, 2026
概括
一些全身性药物可能会增加白内障手术的风险,而其他药物,如美曼丁和里瓦斯蒂格明,可能会降低风险. 需要进一步的研究来确认这些关联,并了解潜在的混因素.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 白内障手术是一种常见的手术,识别影响白内障发生率的因素对公共卫生至关重要.
- 系统性药物被广泛使用,它们对眼睛健康的潜在影响,特别是白内障的形成,需要进行调查.
研究的目的:
- 调查系统性药物使用与大量芬兰人群中白内障手术发生的相关性.
- 为了确定可能增加或减少需要白内障手术的风险的特定药物.
主要方法:
- 一个历史上的队列研究,利用来自Fin-CARING人口的行政数据 (1996-2017年).
- 采用了一个嵌套的病例控制设计,比较了17811名接受白内障手术的个人和76532名匹配的对照.
- 药物使用是由156种系统性药物的赎回处方来确定,并使用条件后勤回归进行分析.
主要成果:
- 几种药物与白内障手术的风险增加有关,包括拉米普利尔,洛萨坦,比索普罗罗尔,阿姆洛迪平,迪尔蒂亚泽姆,异化物单酸盐,富洛塞米德,他类药物 (西姆瓦斯塔丁,阿托瓦斯塔丁),普雷迪诺,阿洛普林醇,普拉米佩克索尔,丸激素,雌激素,氧泽,塞特拉林和佐皮克隆.
- 相反,使用美曼丁,瑞斯佩里,里瓦斯蒂格明和多内佩西尔与白内障手术风险降低有关.
- 对于每个关联,报告了几率比率 (OR) 和95%置信区间 (CI).
结论:
- 这项大型嵌套病例控制研究表明,特定的全身药物可能会影响手术治疗白内障的发生率.
- 这些发现突出了与药物相关的潜在风险和对白内障手术的保护作用.
- 应考虑影响观察到的关联的残留混因素的可能性.
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