CCDC97是癌症诊断中的一个有前途的预测器:泛癌症分析
Changye Yang1, Ruirui Yang2, Rundong Wang3
1Department of Clinical Medicine, Affiliated Huishan Hospital of Xinglin College, Nantong University, No.2 Zhanqian North Road, Wuxi, 214000, Jiangsu, China, ntu.edu.cn.
Analytical cellular pathology (Amsterdam)
|March 11, 2026
概括
卷曲卷曲域含有97 (CCDC97) 在癌症中高度表达,与预后不佳和免疫细胞透相关. CCDC97作为预后和免疫治疗标记物具有前景,特别是在肝细胞癌 (HCC) 中.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 卷曲-卷曲域含有97 (CCDC97) 与SF3B剪接因子复合体相互作用,影响了mRNA前剪接.
- 在CCDC97的机制中出现的障碍可能会导致癌症的发展,这需要进一步的研究.
研究的目的:
- 为了对CCDC97.97进行全面的癌症分析.
- 为CCDC97.7建立一个具有竞争力的内源RNA (ceRNA) 网络.
- 探索CCDC97异常表达背后的致癌机制.
主要方法:
- 在数据库中搜索CCDC97.97的综合癌症分析.
- 建立一个基于CCDC97的ceRNA网络.
- 与已知的CCD家族瘤基因机制的整合.
主要成果:
- CCDC97在各种癌症中表现高,与预后不佳有关.
- CCDC97与瘤微环境中的免疫细胞透和免疫检查点相关.
- CCDC97在肝细胞癌 (HCC) 组织中高度表达,并与枯竭的T细胞相关.
结论:
- CCDC97是癌症的潜在预后和免疫治疗标记物,特别是HCC.
- 需要进一步的实验验证,以确认CCDC97的作用.
更多相关视频
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
2.3K
10:02Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
Published on: December 19, 2025
659
相关概念视频
Cancer Survival Analysis
808
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
808
Cancer-Critical Genes II: Tumor Suppressor Genes
10.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.0K
