心力衰竭患者的风险预测与保存的喷射分数:LIFE-保存模型
Tessa H Reitsma1, Gianluigi Savarese2, Łukasz Kuźma3,4,5
1Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands.
European heart journal
|March 11, 2026
概括
该LIFE-Preserved模型准确地预测了心力衰竭患者的短期和终身心力衰竭住院或心血管疾病死亡风险,心力衰竭患者的心力衰竭与保存喷射分数 (HFpEF). 该工具有助于识别有针对性的预防治疗的高风险个体.
科学领域:
- 心脏病学 心脏病学
- 临床预测模型临床预测模型
- 公共卫生 公共卫生
背景情况:
- 保持喷射分数 (HFpEF) 的心力衰竭是越来越令人担忧的异质患者预后.
- 准确的风险分层对于确定从干预中获益最多的HFpEF患者至关重要.
- LIFE-Preserved模型旨在解决改善风险预测的需求.
研究的目的:
- 开发和验证LIFE-Preserved模型,用于预测HFpEF患者的个人短期和终身HF住院或心血管 (CV) 死亡风险.
- 为确定高风险HFpEF个体提供一种工具,以优化临床管理.
主要方法:
- 该LIFE-Preserved模型是使用瑞典HF注册表 (SwedeHF) 中20332名HFpEF患者的数据得出的.
- 原因和性别特定的考克斯模型结合了14个常规可用的预测因素,使用年龄作为延长预测的时间表.
- 在两个临床试验和三个注册表中进行了外部验证,评估了歧视和校准.
主要成果:
- 该模型在28,062名来自外部来源的HFpEF患者中得到了验证,显示出良好的性能.
- 在所有验证数据集中进行了充分校准后,试验中的C统计数据是0.714和注册表中的0.658,所有验证数据集都进行了充分校准.
- 模型的性能在两性之间是一致的,并且可以使用交互式计算器.
结论:
- 该LIFE-Preserved模型有效地预测了HFpEF患者中HF住院或心血管死亡的短期和终身风险.
- 该模型可以作为一种有价值的临床工具,用于识别高风险患者,指导治疗决策和共享决策.
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