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源自母体微生物组的酸通过基因素乳化调节后代的髓化

Yan Zhang¹, Bing Han¹, Xuan Wang²

¹Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710119, The People's Republic of China.

Brain : a journal of neurology

|March 11, 2026

概括

母亲的肠道微生物影响后代的大脑发育. 作为一种微生物代谢物,酸 (PA) 通过表观遗传调节寡类细胞分化来促进髓的形成,为脱髓化疾病提供了潜在的治疗方法.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

母亲肠道微生物组通过代谢物信号传递影响后代的神经发育.
母亲微生物组在中枢神经系统 (CNS) 髓生成中的作用尚不清楚.

研究的目的:

研究母体肠道微生物组代谢物在后代中枢神经系统骨髓生成中的作用.
为了确定特定的微生物代谢物,调节寡头细胞前体细胞 (OPC) 的分化.

主要方法:

在小鼠中的抗生素诱导的孕产妇肠道失生症模型.
评估后代的髓化和OPC分化.
用酸 (PA) 补充剂来挽救失生效应.
机理学研究涉及基因激素乳酸和基因表达分析.

主要成果:

孕产妇的抗生素失调会导致后代的低髓化,这种情况通过补充PA可以逆转.
PA增强了发育性髓化,并在脱髓化后促进了复髓化.
在PA诱导的素H4K12乳化 (H4K12la),激活cGMP-PKG信号传递和Sox转录因子,这些因子对寡类细胞分化至关重要.

结论:

酸 (PA) 作为一种表观遗传调节剂,将母体肠道微生物代谢与后代骨髓化联系起来.
确定了一种新的PA-H4K12la-cGMP-PKG通路,对于寡细胞分化至关重要.
PA代表了一种潜在的SCFA介导的表观遗传策略,用于治疗中枢神经系统脱髓化的疾病.

关键词:

在OPC中,OPC是指OPC.乳化乳化乳化母亲的肠道微生物组骨髓化骨髓化复黄化是复黄化的一种.

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