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一个更新的胆汁酸调节信号在代谢功能障碍相关的脂肪性肝病的发病

Jiang-Shan Shi¹, Yi Wen¹, Lu Wang²

¹College of Integrated Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.

Liver international : official journal of the International Association for the Study of the Liver

|March 11, 2026

概括

胆汁酸 (BAs) 是影响代谢功能障碍相关的脂肪性肝病 (MASLD) 的关键信号分子. 准BA调节的途径,特别是法尔内索伊德X受体 (FXR) 激活,显示出新型MASLD治疗的前景.

科学领域:

肝病学肝病学是一种肝病学.
代谢障碍代谢障碍代谢障碍
分子信号传输的方法

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题,缺乏有效的治疗方法.
胆汁酸 (BAs) 越来越被认为是影响脂质平衡和MASLD病原性的关键信号分子.
BA信号涉及核受体 (FXR,VDR,PXR) 和G蛋白结合受体 (TGR5,S1PR2),影响肝脏和肝外组织.

研究的目的:

探索胆酸信号通路在MASLD发展中的作用.
审查当前和新兴的治疗策略,针对MASLD的BA调节途径.
突出FXR激活剂和天然化合物的潜力,用于开发新型抗MASLD药物.

主要方法:

对MASLD中的胆酸信号研究的文献综述.
对BA受体 (FXR,VDR,PXR,TGR5,S1PR2) 的作用机制的分析.
对FXR激动剂的临床试验数据的检查和调节BA信号的自然化合物的研究.

主要成果:

胆酸受体,特别是FXR,在调节脂质代谢和MASLD进展方面发挥着重要作用.
像obeticholic 酸, cilofexor 和 tropifexor 这样的 FXR 激活剂在 MASLD. 的临床试验中显示出治疗潜力.
天然化合物如超化物,凯姆菲洛和沙利德化物显示出与MASLD治疗相关的FXR调节性质.

结论:

准胆汁酸信号通路,特别是FXR激活,是MASLD的一个有希望的治疗途径.
对BA信号机制和向疗法的进一步研究可能会导致对MASLD的新有效治疗方法.
调节BA信号的天然化合物为未来的抗MASLD药物开发提供了潜力.

关键词:

马斯尔德马斯尔德是什么意思胆酸信号传递的胆酸信号胆汁酸胆汁酸胆汁酸脂质新陈代谢脂质新陈代谢自然化合物自然化合物有针对性的治疗.

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