饮食盐会影响盐敏感高血压患者的循环生理代谢适应
Lashodya V Dissanayake1, Adrian Zietara1, Ratnakar Tiwari1,2
1Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Function (Oxford, England)
|March 11, 2026
概括
删除核心时钟蛋白Per1会使盐敏感高血压和大鼠损伤恶化. 高盐饮食会破坏脏中的每日基因表达节奏,影响免疫和代谢途径.
科学领域:
- 时间生物学和脏生理学
- 高血压和病的分子机制
背景情况:
- 循环节律由核心时钟蛋白调节 (例如PER,CRY,CLOCK,BMAL1),对于包括血压调节在内的生理过程至关重要.
- 以前的研究表明,在达尔盐敏感 (SS) 鼠中,Per1的缺失加剧了高血压,损伤,并扰乱了血压节奏.
研究的目的:
- 在盐敏感高血压的背景下,调查转录组和蛋白质组的日间变化,基因型和饮食依赖的变化.
- 了解Per1删除和高盐饮食如何影响功能和昼夜调节.
主要方法:
- 皮质样本从SS和SS Per1-/-大鼠中收集,这些大鼠被食正常盐 (NS) 或高盐 (HS) 饮食.
- 样品在活跃 (夜间) 和不活跃 (日间) 期间使用大量RNA测序和蛋白质组分析进行分析.
- 使用路径和蛋白质组分析来确定关键的分子变化.
主要成果:
- 高盐饮食使SS老鼠的白天转录变化变得,预测了显著的压力,免疫反应和代谢适应.
- 酸盐脱酶复合物的重塑被确定为HS饮食影响的关键途径,无论是在转录和蛋白质组数据中.
- 1删除进一步恶化了免疫调节和代谢适应的障碍.
结论:
- 许多脏基因表现出在盐敏感高血压中被破坏的白天振荡,导致功能受损.
- 基因表达的循环 misalignment,特别是关于免疫和代谢途径,在高血压和病中起作用.
- 在对盐敏感高血压的背景下,Per1是脏昼夜节律和代谢平衡的关键调节者.
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