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Updated: Mar 12, 2026

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乳酸酸通过向GluN2B子单元的细胞内氧化还原机制强化NMDA受体电流:对突触可塑性的影响

Hubert Fiumelli1, Gabriel Herrera-López1, Fouad Lemtiri-Chlieh1,2

  • 1Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.

The Journal of physiology
|March 11, 2026
PubMed
概括

星球细胞衍生的乳酸盐通过增强NMDA受体活性来增强神经元功能. 这一过程涉及代谢转化和CaMKII与GluN2B的相互作用,将天体细胞能量与突触可塑性和记忆联系起来.

关键词:
GluN2B 的子单位.纳米多氨酸受体 (NMDAR) 是一种NMDA受体./卡尔莫杜林依赖的蛋白激酶II (CaMKII) 蛋白乳酸乳酸是一种乳酸.氧化还原状态 氧化还原状态信号信号是指一个信号.突触性可塑性 突触性可塑性

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