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通过激活ADAM10-NOTCH信号通路,LECT2促进了整个发育阶段的肝脏再生

Hui Zhang1,2, Wei Wang1, Yufeng Gao3,4

  • 1Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Hepatology communications
|March 11, 2026
PubMed
概括

白细胞细胞衍生的化学毒素2 (LECT2) 通过激活ADAM10-NOTCH通路,促进肝脏在所有发育阶段的再生. 过度表达LECT2增强了肝脏的修复能力,为肝脏再生提供了潜在的治疗点.

关键词:
一个分解蛋白和金属蛋白酶10 (ADAM10)在NOTCH信号通道上.白细胞细胞衍生的化学毒素-2 (LECT2)肝脏再生 肝脏再生转录基因测序 (RNA-seq) 是一种转录基因测序.

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