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瘤免疫微环境 (TIME) 中HIF-1a与各种细胞死亡途径的相互作用

Mahsa Manafi Varkiani¹, Ferdos Faghihkhorasani², Mona Moosavi³

¹Innovative Medical Research Center, Faculty of Medicine, Mashhad Medical Science, Islamic Azad University, Mashhad, Iran.

Apoptosis : an international journal on programmed cell death

|March 11, 2026

概括

缺氧诱导因子-1α (HIF-1α) 通过改变瘤免疫微环境 (TIME) 中的细胞死亡途径来驱动瘤免疫逃避. 向HIF-1α可能会改善缺氧瘤的癌症免疫治疗反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

缺氧诱导因子-1α (HIF-1α) 对于瘤适应缺氧至关重要.
HIF-1α影响血管新生,新陈代谢,细胞死亡,以及瘤免疫微环境 (TIME).
这些作用会影响免疫逃避和对癌症治疗的抵抗力.

研究的目的:

系统地审查HIF-1α和调控细胞死亡 (RCD) 途径之间的相互作用.
分析它们对"时代"的综合影响.
探索癌症免疫疗法反应的影响.

主要方法:

根据PRISMA指南进行全面的文献搜索 (PubMed,Scopus,科学网).
包括临床前,体内和临床研究.
独立的数据提取和质量评估由两个审查员进行.

主要成果:

七十项研究被纳入了审查.
HIF-1α通过培养免疫抑制的TIME成分来促进瘤免疫逃生.
HIF-1α 抑制了亡,并且在情境上调节了 pyroptosis 和 ferroptosis.

结论:

HIF-1α,RCD和TIME之间的交声是理解瘤适应性和免疫抵抗力的关键.
针对这一轴提出了新的治疗策略.
增强癌症免疫疗法,特别是在低氧瘤中,是一种潜在的益处.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.铁化是铁化的一种.免疫逃逸是一种免疫逃避.免疫原性细胞死亡尸体灭 (Necroptosis) 是一种死亡的过程.热灭菌的发生.调节的细胞死亡.瘤免疫微环境 (时间)

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