宿主微生物共同调节调解乳母奶牛的乳头挥发性脂肪酸的生产和利用
Wei Wang1, Jianrong Ren1, Jing Li1
1College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Science China. Life sciences
|March 11, 2026
概括
液中挥发性脂肪酸 (VFA) 是反动物的主要能量来源. 这项研究揭示了宿主遗传学,肠微生物和基因表达如何共同调节VFA的生产和利用,优化料效率.
科学领域:
- 动物科学动物科学
- 微生物组研究 微生物组研究
- 基因组学就是基因组学.
背景情况:
- 挥发性脂肪酸 (VFA) 是反动物的重要能量来源,来自于反动物的微生物发酵.
- 优化VFA生产和利用对于提高牲畜料能源效率至关重要.
研究的目的:
- 调查复杂的监管机制的VFA生产和利用在反动物.
- 确定影响VFA度的宿主遗传,微生物和基因表达因素.
- 探索主体微生物相互作用,控制VFA代谢.
主要方法:
- 全基因组再测序,转录组测序和16S rRNA基因片测序在530只霍尔斯坦公牛身上进行.
- 进行了多种OMIC关联分析,以将宿主遗传,微生物群落和基因表达与VFA度联系起来.
- 门德尔的随机化被用来确定与VFA的潜在因果微生物关系.
主要成果:
- 主体遗传学,肠微生物群和肠基因表达分别解释了23%,58%和61%的VFA变异.
- 在高VFA和低VFA个体之间观察到微生物组成的显著差异.
- 确定了11种与VFAs潜在的因果关系的微生物,参与脂肪酸代谢的特定皮基因与VFAs负相关.
结论:
- 宿主遗传学,肠微生物群和基因表达是反动物中VFA代谢的重要调节者.
- 主体-微生物相互作用在有效生产和利用VFA中发挥着关键作用.
- 这项研究提供了通过了解VFA监管网络来优化反动物料利用的见解.
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