乳托费林对肥胖儿童和患有代谢功能障碍相关的肥胖性疾病的青少年的影响:一项随机对照研究
Doaa El Amrousy1, Dalia El-Afify2, Esraa Abd Al-Fattah Sorour3
1Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt. doaa.moha@med.tanta.edu.eg.
Paediatric drugs
|March 11, 2026
概括
乳二烯补充剂显著降低体重,改善胰岛素耐药性,并降低肥胖儿童的炎症标志物脂肪肝疾病. 这表明,乳酸是儿科代谢功能障碍的潜在治疗剂.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 乳酸是牛奶中的一种结合铁的葡萄糖蛋白,具有免疫调节,抗氧化和抗炎性质.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 在肥胖儿童和青少年中越来越普遍.
- 对儿科MASLD的新型治疗策略的研究至关重要.
研究的目的:
- 评估乳酸在被诊断为MASLD的肥胖儿童和青少年的疗效.
- 评估乳酸对人体测量,代谢和炎症标志物的影响.
主要方法:
- 一项随机对照试验,涉及73名患有MASLD的肥胖儿童/青少年.
- 干预组每天接受100毫克乳酸3个月;对照组没有干预.
- 两组都遵循低热量饮食;在基线和干预后测量了各种临床参数.
主要成果:
- 乳托费林组的体重,BMI,ALT,AST,禁食葡萄糖和HOMA-IR显著减少.
- 与对照组相比,脂质样本,同型半氨酸,马隆迪化物和IL-6水平有所改善.
- 70名参与者完成了这项研究,具有强大的统计学意义 (关键标志物的p < 0.001).
结论:
- 乳酸补充剂可能对患有MASLD的肥胖儿童的体重管理有益.
- 它显示出改善胰岛素耐药性和脂质特征的潜力.
- 乳酸可能有助于减少与儿科MASLD相关的氧化应激和炎症.
相关概念视频
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
262
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
262
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
342
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
342