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血小板计数和血小板指数作为COVID-19死亡率的预测标记

Z Kozelová¹, D Jarčušková, L Tomčo

¹Fourth Department of Internal Medicine P.J. Safarik University, L. Pasteur University Hospital, Košice, Slovak Republic. miriam.kozarova@upjs.sk.

Physiological research

|March 11, 2026

概括

平均血小板体积 (MPV) 是住院COVID-19患者死亡率的强有力的预测指标,其表现优于中性粒细胞与淋巴细胞比率 (NLR). 这种可访问的血液测试参数有助于在COVID-19患者管理的早期风险分层.

科学领域:

血液学血液学血液学
传染性疾病传染性疾病
关键护理医学关键护理医学

背景情况:

COVID-19 感染与血小板指数的改变有关.
中性粒细胞与淋巴细胞的比率 (NLR) 是一种已知的COVID-19严重程度的标志物.
血小板指数的预后价值,特别是平均血小板体积 (MPV),在COVID-19死亡率需要进一步调查.

研究的目的:

分析住院COVID-19患者血小板计数和功能的变化.
为了比较COVID-19和非COVID-19患者之间的血小板指数.
评估COVID-19患者血小板指数和死亡率之间的关联,比较MPV与NLR的预测能力.

主要方法:

对572名患者 (472名COVID-19,100名对照) 的回顾性分析.
组间血小板计数和指数 (MPV,P-LCR,PLT,PCT) 的比较.
多变量逻辑回归分析以评估死亡率预测因素 (MPV,年龄,NLR).

主要成果:

与对照组相比,COVID-19患者的血小板显著增加 (MPV增加) 和P-LCR增加.
COVID-19患者的死亡率与较高的MPV,P-LCR,PLT/MPV比率,PDW/PCT,NLR以及较低的PLT和PCT有关.
在多变量分析中,MPV是死亡率的显著独立预测指标,显示出比NLR更强的预后值.

结论:

平均血小板体积 (MPV) 是住院COVID-19患者死亡率的强大和独立预测指标.
与NLR相比,MPV在COVID-19死亡率方面显示出更高的预后价值.
常规可用的参数MPV可以作为COVID-19管理中早期风险分层的实际工具.

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