双层溶解微针,用于用微乳液介导的布里莫尼丁酸盐在玻璃眼癌治疗中的眼部输送
Nisha Rajbhar1, Harsh P Nijhawan1, Khushwant S Yadav1
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS (Deemed to be University), Mumbai, India.
Journal of biomaterials science. Polymer edition
|March 11, 2026
概括
一种新型的微针系统可以有效地提供布里莫尼丁酸盐 (BRT),降低青光眼患者的眼内压力 (IOP). 这种先进的药物输送改善了保留和疗效,提供了更好的治疗选择.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 药品制造 药品制造 药品制造
背景情况:
- 玻璃眼瘤是全球不可逆转失明的主要原因,通常与眼内压力 (IOP) 升高有关.
- 目前的布里莫尼丁酸 (BRT) 眼滴具有局限性,包括快速清除和较差的角膜透,导致合规问题.
- 需要持续的眼部药物输送系统来改善绿眼管理的治疗结果.
研究的目的:
- 开发和评估基于微乳液 (ME) 的双层溶解微针 (BDMNs) 系统,用于持续向眼部输送布里莫尼丁酸盐 (BRT).
- 优化BRT-ME配方,并评估BDMNs系统的性能,以改善绿眼治疗.
主要方法:
- 使用D-最佳设计优化BRT-ME配方,以滴滴大小,粘度,清晰度和稳定性为特征.
- 集成优化ME到一个双层微针矩阵 (PVA,奇托桑,Poloxamer 407) 具有高机械完整性.
- 在子模型中评估了BRT释放动力学,ex vivo角膜透,眼部刺激和体内IOP降低.
主要成果:
- 优化的BRT-ME表现出有利的物理化学特性和热力学稳定性.
- 该BDMN系统表现出强大的机械完整性和高插入效率.
- 观察到持续的BRT释放 (>95%在24小时内) 和增强的角膜透.
- 在体内研究表明,显著的IOP降低 (~47%) 优于单独的BRT-ME,具有很好的生物相容性.
结论:
- BRT-ME-BDMNs系统为持续的眼部药物输送提供了一个稳定,最小侵入性的平台.
- 这种新的系统显著提高了药物保留率和治疗疗效,用于治疗青光眼.
- BRT-ME-BDMNs代表了一种有前途的下一代方法,用于有效的青光眼治疗.
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