相关实验视频

Updated: Mar 13, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

CD47 经典霍奇金淋巴瘤的表达及其与瘤微环境的关联

Xiaoyue Xiao¹, Lin Nong¹, Yiyang Luo¹

¹Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China, pumc.edu.cn.

Journal of immunology research

|March 11, 2026

概括

经典霍奇金淋巴瘤 (CHL) 中高CD47表达与预后较差和PD-L1.1增加相关. 向CD47和PD-1/PD-L1可能为CHL患者提供新的治疗策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
血液学血液学血液学

背景情况:

47分化集群 (CD47) 在许多癌症中过度表达,与糟糕的结果有关.
在经典霍奇金淋巴瘤 (CHL) 中CD47的作用,其免疫检查点和瘤微环境 (TME) 尚不清楚.

研究的目的:

研究CD47在CHL中的表达和预后意义.
探索CD47,免疫检查点 (PD-1/PD-L1) 和CHL中TME之间的关联.

主要方法:

关于CHL瘤组织的免疫组织化学和公共数据集的分析 (GSE17920).
评估CD47,PD-1和PD-L1在瘤细胞和TME中的表达.
卡普兰-梅尔曲线,考克斯回归和生物信息分析 (基因表达,通过CIBERSORT进行免疫透).

主要成果:

在瘤细胞中的高CD47表达 (CD47tumor_score) 和TME (CD47micro_score) 与较差的无进展生存 (PFS) 相相关.
高CD47micro_score预测了较低的整体存活率 (OS).
CD47表达与PD-L1有积极的相关性,并且与化学激素信号传递,免疫细胞迁移以及增加M1巨细胞,中性粒细胞和乙素细胞透有关.

结论:

CD47表达与CHL的疾病进展和预后有关.
CD47显示出与PD-L1表达的强烈正相关性.
联合向CD47和PD-1/PD-L1可能是CHL的一种有前途的治疗方法.

关键词:

CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 经典的霍奇金淋巴瘤免疫检查点的检查点.预后预后预后

更多相关视频

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...