数据驱动的表型化揭示了大动脉手术后年龄和死亡率之间的不均关联:英国生物库数据的回顾性队列研究
Maria Elisabeth Leinweber1, Fadi Taher1, Miriam Kliewer1
1Department of Vascular and Endovascular Surgery, Klinik Ottakring, Montleartstraße 37, Vienna, 1160, Austria, 43 1491504103.
JMIR aging
|March 11, 2026
概括
年龄是侵入性大动脉治疗结果的关键因素. 老年患者面临更高的死亡风险,但手术后年龄和存活率之间的关系是复杂的,并且因年龄组而异.
科学领域:
- 心血管外科心血管外科
- 老年医学 老年医学
- 医学统计 医学统计
背景情况:
- 年龄和预期寿命对于评估大动脉病理患者的风险至关重要.
- 这些因素影响了对大动脉疾病的侵入性治疗的决定.
研究的目的:
- 为了研究患者年龄和入侵性大动脉治疗后的全因死亡率之间的关联.
- 了解年龄如何影响大动脉动脉瘤外科手术或内血管修复后的生存结果.
主要方法:
- 在英国生物库数据上使用无监督集群 (k-means) 对有大动脉病理患者 (ICD-10组I71) 的数据.
- 包括人口和临床参数用于集群.
- 进行了生存分析,以比较分类和年龄组之间的术后生存率.
主要成果:
- 确定了不同的患者群,主要是根据年龄在1801名接受大动脉修复的人群中.
- 老年患者群体的术后存活率较低,术后死亡率较高.
- 年龄和死亡率之间的关联在老年群体中减弱,当排除外科手术期间死亡时.
结论:
- 年龄是接受入侵性大动脉治疗的患者群体的主要差异化因素.
- 手术时的年龄和术后死亡率之间的关系是复杂的,并且在不同年龄段是不统一的.
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