在自闭症谱系障碍中,前带带膜折叠模式发生变化
Ethan H Willbrand1,2,3, Enrique Martinez4, Jacob J Ludwig1
1School of Medicine and Public Health, University of Wisconsin-Madison, Health Sciences Learning Center, 750 Highland Ave, Madison, WI 53705, United States.
Cerebral cortex (New York, N.Y. : 1991)
|March 11, 2026
概括
神经成像揭示了自闭症谱系障碍 (ASD) 的男性大脑折叠模式的差异. 神经类型的个体表现出更不对称的状状硫模式,这表明早期大脑发育的变化.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 自闭症谱系障碍研究研究
背景情况:
- 大脑皮层的焦点差异,特别是形模式,在患有自闭症谱系障碍 (ASD) 的个体中观察到.
- 前带带皮质 (ACC) 在社会认知和执行功能中起着至关重要的作用,这些区域在ASD中经常受到影响.
研究的目的:
- 研究ASD与神经型 (NT) 对照对象相比,男性ASD中ACC的状模式和形态,特别是状状 (PCGS),进行研究.
- 为了确定PCGS不对称性或定量形态特征是否在ASD和NT组之间存在差异.
主要方法:
- 利用来自200名男性参与者的神经成像数据 (100名ASD,100名NT,年龄5-18岁),分为发现和复制样本.
- 手动识别PCGS,一个关键的ACC状特征,并使用FreeSurfer提取定量形态数据 (长度,深度,皮质厚度).
- 进行统计分析,控制年龄,智商和扫描器位置,以比较ASD和NT组之间的PCGS模式和形态.
主要成果:
- 与ASD参与者相比,神经类型参与者在发现和复制样本中显示出不对称的PCGS模式的可能性显著更高.
- 在PCGS的定量形态特征 (长度,深度,皮层厚度) 中,在ASD和NT组之间没有发现显著差异.
- 这些发现在两个独立样本中都是一致的,加强了它们的可靠性.
结论:
- 这项研究表明,在患有自闭症的年轻男性中,ACC的产前神经发育可能存在变化,这种变化是由改变的PCGS模式表明的.
- 虽然PCGS不对称性可能代表神经发育障碍中的特征标记,但它在ASD病原体中的特定作用需要进一步调查.
- 这项研究有助于理解ASD中的神经解剖学差异,并突出了PCGS变异作为生物标志物的潜力.
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