这是正常的还是不正常的? 体形态不是一个二进制分类
Connor J Green1, Siobhan Hoare, David Podeszwa
1From the School of Mechanical & Materials Engineering, University College Dublin, Dublin, Ireland (Green, Hoare, and Nowlan), the Children's Health Ireland, Dublin, Ireland (Green and Hoare), the National Orthopaedic Hospital at Cappagh, Finglas, Dublin, Ireland (Green), the Scottish Rite for Children, Dallas, Texas (Podeszwa), and the UCD Conway Institute, University College Dublin, Dublin, Ireland (Nowlan).
骨科部形症测量通常基于过时的数据,这可能会阻碍骨关节炎进展的评估. 重新评估这些传统模型对于准确的临床决策和患者结果至关重要.
科学领域:
- 整形外科手术 整形外科手术
- 放射学 放射学是一门学科.
- 生物统计学 生物统计学
背景情况:
- 骨科决策依赖于临床判断,放射学测量和标准.
- 部病理通常被视为机械问题,使用几何和统计方法进行分析.
- 有用的临床测量必须是简单的,可重复的,并与疾病风险相关联.
研究的目的:
- 批判性地评估当前的放射测量,以评估关节发育不良的风险.
- 区分基于人口的规范性数据和基于结果的决策限制.
- 追踪支持常用的部形态测量的证据.
主要方法:
- 审查关键部测量的起源,当前应用和统计有效性.
- 对特定角度和分类的可复制性和临床决策实用性的分析.
- 审查命名规范的漂移和数据集验证问题.
主要成果:
- 常见的部测量,如横向中心边缘角和托尼斯角,与它们的参考数据集相比具有可疑的验证性.
- 名称不一致导致临床实践中的错误沟通.
- 目前的表型风险模型可能不如连续剂量反应模型有效.
结论:
- 关节硬化症的遗传形态风险模型可能无法有效地减少骨关节炎的进展.
- 需要重建或从根本上重新评估部形态评估模型.
- 临床依赖未经验证或过时的测量值得严格审查.
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