与代谢功能障碍相关的脂肪性肝病和随着重血管化的冠状动脉事件:一项全国性的队列研究
Minhong Kim1, Hyun-Ah Lee2, Joungyoun Kim3
1Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Atherosclerosis
|March 11, 2026
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 显著增加了急性冠状动脉综合征和心肌梗塞的风险. 这些发现凸显了MASLD作为预防心血管疾病的关键早期标志物.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,与心血管疾病有关.
- 之前的研究在定义心血管结果方面缺乏临床特异性.
- 这项研究调查了MASLD与特定心血管事件的关联.
研究的目的:
- 确定通过脂肪肝指数 (FLI) 识别的MASLD是否会增加急性冠状动脉综合征 (ACS) 和心肌梗塞 (MI) 的风险.
- 分析韩国普通人口中的这些风险.
- 提供超出广泛心血管结果定义的具体临床见解.
主要方法:
- 对来自NHIS-HEALS队列的211,881名韩国成年人的分析 (2009-2010).
- 按FLI (≥30) 加上代谢风险因素定义的MASLD,不包括酒精/病毒性肝炎.
- 通过诊断和程序代码确定主要结局 (ACS,重血管化的MI);用于分析的Cox模型.
主要成果:
- 患有MASLD的个人表现出更高的ACS和MI发病率.
- 在男性和女性患有MASLD时,随着再血管化的ACS完全调整后的HRs都增加了.
- 在心脏病发作和再血管化时观察到类似的关联.
结论:
- 马斯尔德与ACS和MI的风险增加显著相关,需要重新血管化.
- 这些结果支持MASLD作为动脉样硬化心血管疾病的早期指标.
- 对于心血管疾病预防战略来说,MASLD是一个潜在的目标.
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