22种生化分析物的特定人口参考区间:在多民族地区应用三种间接方法
Shengxi Zhang1, Hua Zhang2, Yan Li3
1School of Medicine, Tarim University, Alar, 843300 Xinjiang, People's Republic of China.
概括
生物化学分析物的参考间隔 (RIs) 根据多民族人口的性别和年龄进行了调整. 种族影响阿波利波蛋白AI,需要量身定制的RI以提高临床准确性.
科学领域:
- 临床生物化学 临床生物化学
- 人口健康 人口健康
- 医学诊断 医学诊断 医学诊断
背景情况:
- 参考间隔对于解释实验室测试结果至关重要.
- 固定的RI通常在多民族地区使用,尽管人口差异很大.
- 为了准确的健康评估,需要特定人群的RI.
研究的目的:
- 为常规生化分析物建立适应人群的参考间隔 (RIs).
- 研究性别,年龄和种族对维吾尔族和汉族成年人生物化学分析物的影响.
- 为了比较导出RI的间接算法.
主要方法:
- 追溯分析了1,825,257个实验室测试结果.
- 差异组件分析以评估人口统计学贡献 (性别,年龄,种族).
- 间接算法 (宇宙,RefineR,霍夫曼) 和GAMLSS用于RI导出和年龄依赖建模.
主要成果:
- 对于大多数分析对象来说,性别是变化的主要决定因素.
- 种族显著影响了阿波利波蛋白A-I (ApoA-I) 水平,维吾尔人的下限较低.
- 持续的年龄依赖性RI显示了老年人 (≥60岁) 的特定变化.
结论:
- 性别和年龄是影响生物化学变异性的关键因素.
- 种族具有选择性但临床相关的影响,特别是对ApoA-I.
- 数据驱动的间接RI对不同人群来说是实用的,提高了诊断准确度.
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